A nonclassical vitamin D receptor pathway suppresses renal fibrosis.

Vitamin D suppresses cellular pathways of diabetes complication in liver

Objective(s): The aim of this study was to investigate the effect of vitamin D on glucose metabolism, as well as the expression of five key genes involved in the development of diabetes complications in liver tissue of diabetic rats. Materials and Methods: Twenty-four male Sprague–Dawley rats were randomly divided into three groups (8 ra...

Evaluation of the relationship between different polymorphisms of vitamin D receptor gene and renal diseases in patients with type 2 diabetes in Khuzestan province

Antifibrotic vitamin D analogs.

Chronic kidney disease is associated with progressive kidney fibrosis, which disrupts normal kidney function. There is a great need for treatments to reduce renal fibrosis. In this issue of the JCI, Ito and colleagues report the development of synthetic ligands of the vitamin D receptor that target the TGF-β-SMAD signaling pathway, which is known to regulate fibrosis-associated gene expression,...

Anti-inflammatory and anti-apoptotic effects of paricalcitol in lipopolysaccharide-induced renal proximal tubular cell injury

regulator of calcium and bone metabolism. The classical actions of vitamin D are related to mineral metabolism and skeletal health. Recently, the nonclassical actions of vitamin D have also been shown to play an important role in the regulation of cellular proliferation, differentiation and inflammation [1]. In clinical practice, hypercalcemia is a common side effect of vitamin D administration...

1,25-Dihydroxyvitamin D3 suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-{kappa}B pathway.

The renin-angiotensin system (RAS) is a major mediator of renal injury in diabetic nephropathy. Our previous studies demonstrated that 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] plays a renoprotective role by suppressing the RAS, with renin and angiotensinogen (AGT) as the main targets. The mechanism whereby 1,25(OH)(2)D(3) transcriptionally suppresses renin gene expression has been elucidate...